A low-dimensional cognitive-network space in Alzheimer's disease and frontotemporal dementia.

ABSTRACT:

Background

Alzheimer's disease (AD) and frontotemporal dementia (FTD) show network dysfunctions linked with cognitive deficits. Within this framework, network abnormalities between AD and FTD show both convergent and divergent patterns. However, these functional patterns are far from being established and their relevance to cognitive processes remains to be elucidated.

Methods

We investigated the relationship between cognition and functional connectivity of major cognitive networks in these diseases. Twenty-three bvFTD (age: 71±10), 22 AD (age: 72±6), and 20 controls (age: 72±6) underwent cognitive evaluation and resting-state functional MRI. Principal component analysis was used to describe cognitive variance across participants. Brain network connectivity was estimated wit

SUBMITTER: Pini L 

PROVIDER: S-EPMC9798659 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature