Establishment and validation of an aging-related risk signature associated with prognosis and tumor immune microenvironment in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is a highly malignant and heterogeneous tumor which is currently the cancer with the highest incidence and seriously endangers the survival and prognosis of patients. Aging, as a research hotspot in recent years, is widely considered to be involved in the occurrence and development of a variety of tumors. However, the relationship between aging-related genes (ARGs) and BC has not yet been fully elucidated.

Materials and methods

The expression profiles and clinicopathological data were acquired in the Cancer Genome Atlas (TCGA) and the gene expression omnibus (GEO) database. Firstly, the differentially expressed ARGs in BC and normal breast tissues were investigated. Based on these differential genes, a risk model was constructed composed of 11 A

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9798726 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature