Aberrant B-Cell Activation in Systemic Lupus Erythematosus.

ABSTRACT:

Background

B lymphocytes (B cells) are essential in humoral response, and their activation is an important first step for the production of antibodies. However, aberrant B-cell activation is common in the development and progression of autoimmune diseases including systemic lupus erythematosus (SLE), which is characterized by the generation of superfluous autoantibodies. SLE exhibits clinical manifestation such as excessive inflammation and tissue damage. This review aims to summarize the recent emerging studies on aberrant B-cell activation and the associated concurrent therapeutic targets in SLE.

Summary

Aberrant B-cell activation is closely associated with the pathogenesis of SLE. Among a variety of mechanisms, dysregulations of B-cell receptor (BCR), toll-like receptor (

SUBMITTER: Kang N 

PROVIDER: S-EPMC9798842 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature