Brain motor and fear circuits regulate leukocytes during acute stress.

ABSTRACT: The nervous and immune systems are intricately linked¹. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly understood². Here we show that distinct brain regions shape leukocyte distribution and function throughout the body during acute stress in mice. Using optogenetics and chemogenetics, we demonstrate that motor circuits induce rapid neutrophil mobilization from the bone marrow to peripheral tissues through skeletal-muscle-derived neutrophil-attracting chemokines. Conversely, the paraventricular hypothalamus controls monocyte and lymphocyte egress from secondary lymphoid organs and blood to the bone marrow through direct, cell-intrinsic glucocorticoid si

SUBMITTER: Poller WC 

PROVIDER: S-EPMC9798885 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature