N⁶ -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation.

ABSTRACT: Epitranscriptomic remodeling such as N⁶ -methyladenosine (m⁶ A) modification plays a critical role in tumor development. However, little is known about the underlying mechanisms connecting m⁶ A modification and nasopharyngeal carcinoma (NPC) progression. Here, CBX1 is identified, a histone methylation regulator, to be significantly upregulated with m⁶ A hypomethylation in metastatic NPC tissues. The m⁶ A-modified CBX1 mRNA transcript is recognized and destabilized by the m⁶ A reader YTHDF3. Furthermore, it is revealed that CBX1 promotes NPC cell migration, invasion, and proliferation through transcriptional repression of MAP7 via H3K9me3-mediated heterochromatin formation. In addition to its oncogenic effect, CBX1 can facili

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9798977 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature