Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis.

ABSTRACT:

Background

Thickening of the ligamentum flavum is considered to be the main factor for lumbar spinal canal stenosis (LSCS). Although some mechanisms have been speculated in the thickening of the ligamentum flavum, there are only a few comprehensive approaches to investigate its pathology. The objective of this study was to investigate the pathology of thickened ligamentum flavum in patients with LSCS based on protein expression levels using shotgun proteome analysis.

Methods

Ligamentum flavum samples were collected from four patients with LSCS (LSCS group) and four patients with lumbar disc herniation (LDH) as controls (LDH group). Protein mixtures were digested and analyzed by liquid chromatography/mass spectrometry analysis. To compare protein expression levels between the

SUBMITTER: Yabe Y 

PROVIDER: S-EPMC9799084 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature