Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study.

ABSTRACT:

Background

Fatty acids are important dietary factors that have been extensively studied for their implication in health and disease. Evidence from epidemiological studies and randomised controlled trials on their role in cardiovascular, inflammatory, and other diseases remains inconsistent. The objective of this study was to assess whether genetically predicted fatty acid concentrations affect the risk of disease across a wide variety of clinical health outcomes.

Methods and findings

The UK Biobank (UKB) is a large study involving over 500,000 participants aged 40 to 69 years at recruitment from 2006 to 2010. We used summary-level data for 117,143 UKB samples (base dataset), to extract genetic associations of fatty acids, and individual-level data for 322,232 UKB participant

SUBMITTER: Zagkos L 

PROVIDER: S-EPMC9799317 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature