Clonally related, Notch-differentiated spinal neurons integrate into distinct circuits.

ABSTRACT: Shared lineage has diverse effects on patterns of neuronal connectivity. In mammalian cortex, excitatory sister neurons assemble into shared microcircuits. In Drosophila, in contrast, sister neurons with different levels of Notch expression (Notch^ON/Notch^OFF) develop distinct identities and diverge into separate circuits. Notch-differentiated sister neurons have been observed in vertebrate spinal cord and cerebellum, but whether they integrate into shared or distinct circuits remains unknown. Here, we evaluate how sister V2a (Notch^OFF)/V2b (Notch^ON) neurons in the zebrafish integrate into spinal circuits. Using an in vivo labeling approach, we identified pairs of sister V2a/b neurons born from individual Vsx1+ progenitors and observed that

SUBMITTER: Bello-Rojas S 

PROVIDER: S-EPMC9799969 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature