Pharmacodynamics and acute toxicity studies of Shangke Jiegu tablet with or without cinnabar

ABSTRACT:

Purpose

To evaluate the function of cinnabar in Shangke Jiegu tablet (SKJGT) via pharmacodynamics and toxicity investigations to determine whether cinnabar should be removed from SKJGT.

Materials and methods

The pharmacodynamic differences between SKJGT and cinnabar-free Shangke Jiegu tablet (CFSKJGT) were systematically compared in five animal models. Anti-inflammatory effects were assessed on ear swelling and paw edema by measuring the degree of swelling in each. Then, the acetic acid-induced writhing reaction and hot-water tail-flick were also evaluated by counting pain reactions. The pharmacodynamic effects on soft tissue contusions were identified through histopathological observation. Chemical markers of fracture healing, including osteocytes and the blood calcium a

SUBMITTER: Wang T 

PROVIDER: S-EPMC9800192 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature