Whole-body CD8⁺ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial.

ABSTRACT: Immune checkpoint inhibitors (ICIs), by reinvigorating CD8⁺ T cell mediated immunity, have revolutionized cancer therapy. Yet, the systemic CD8⁺ T cell distribution, a potential biomarker of ICI response, remains poorly characterized. We assessed safety, imaging dose and timing, pharmacokinetics and immunogenicity of zirconium-89-labeled, CD8-specific, one-armed antibody positron emission tomography tracer ⁸⁹ZED88082A in patients with solid tumors before and ~30 days after starting ICI therapy (NCT04029181). No tracer-related side effects occurred. Positron emission tomography imaging with 10 mg antibody revealed ⁸⁹ZED88082A uptake in normal lymphoid tissues, and tumor lesions across the body varying within and between patients two days after tra

SUBMITTER: Kist de Ruijter L 

PROVIDER: S-EPMC9800278 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature