Mapping the deficit dimension structure of the National Institutes of Health Stroke Scale.

ABSTRACT:

Background

The National Institutes of Health Stroke Scale (NIHSS) is the most frequently applied clinical rating scale for standardized assessment of neurological deficits in acute stroke in both clinical and research settings. Notwithstanding this prominent role, important questions regarding its validity remain insufficiently addressed: Investigations of the underlying dimensional structure of the NIHSS yielded inconsistent results that are largely not generalizable across studies. Neurobiological validations by linking measured deficit dimensions to brain anatomy and function are missing.

Methods

We, therefore, employ advanced machine learning to identify an optimal representation of the dimensional structure of the NIHSS across two independent and heterogeneous stroke da

SUBMITTER: Cheng B 

PROVIDER: S-EPMC9800288 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature