Delineating the molecular landscape of different histopathological growth patterns in colorectal cancer liver metastases.

ABSTRACT:

Background

Histopathological growth patterns (HGPs) have shown important prognostic values for patients with colorectal cancer liver metastases, but the potential molecular mechanisms remain largely unknown.

Methods

We performed an exploratory analysis by conducting the RNA sequencing of primary colorectal lesions, colorectal liver metastatic lesions and normal liver tissues.

Findings

We found that desmoplastic HGPs of the metastatic lesions were significantly enriched in EMT, angiogenesis, stroma, and immune signaling pathways, while replacement HGPs were enriched in metabolism, cell cycle, and DNA damage repair pathways. With the exception of immune-related genes, the differentially expressed genes of the two HGPs from colorectal liver metastases were mostly inherit

SUBMITTER: Hu M 

PROVIDER: S-EPMC9800416 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature