High-risk subtype: Clinical manifestations and molecular characteristics of submandibular gland adenoid cystic carcinoma

ABSTRACT:

Objective

Adenoid cystic carcinoma of the head and neck mainly occurs in the major salivary glands, of which the parotid gland and submandibular gland are the most common. The purpose of this study was to clarify the site-specific differences in prognosis and molecular expression characteristics of the patients and to achieve stratified risk management of the clinical prognosis.

Materials

By performing a single-centre retrospective analysis combined with analyses of the Surveillance, Epidemiology, and End Results (SEER) database, cBioPortal and GEO databases, the clinical prognostic characteristics and the differences in molecular expression patterns of ACC in the submandibular gland and parotid gland were analysed. Cox regression analysis, the chi-square test, Fisher’s t

SUBMITTER: Zhou M 

PROVIDER: S-EPMC9800506 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature