FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability.

ABSTRACT: Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder emerging in early life characterized by impairments in social interaction, poor verbal and non-verbal communication, and repetitive patterns of behaviors. Among the best-known genetic risk factors for ASD, there are mutations causing the loss of the Fragile X Messenger Ribonucleoprotein 1 (FMRP) leading to Fragile X syndrome (FXS), a common form of inherited intellectual disability and the leading monogenic cause of ASD. Being a pivotal regulator of motor activity, motivation, attention, and reward processing, dopaminergic neurotransmission has a key role in several neuropsychiatric disorders, including ASD. Fmr1 ^Δexon 8 rats have been validated as a genetic model of ASD based on FMR1 deletion, and they ar

SUBMITTER: D'Elia A 

PROVIDER: S-EPMC9800572 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature