A multi-tissue transcriptomic landscape of female mice in estrus and diestrus provides clues for precision medicine.

ABSTRACT: Female reproductive cycle, also known as menstrual cycle or estrous cycle in primate or non-primate mammals, respectively, dominates the reproductive processes in non-pregnant state. However, in addition to reproductive tissues, reproductive cycle could also perform global regulation because the receptors of two major female hormones fluctuating throughout the cycle, estrogen and progesterone, are widely distributed. Therefore, a multi-tissue gene expression landscape is in continuous demand for better understanding the systemic changes during the reproductive cycle but remains largely undefined. Here we delineated a transcriptomic landscape covering 15 tissues of C57BL/6J female mice in two phases of estrous cycle, estrus and diestrus, by RNA-sequencing. Then, a number of genes, pathways,

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9800588 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature