Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.

ABSTRACT:

Introduction

SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants.

Methods

We combined single-cell RNA and T cell receptor sequencing with CITE-seq antibodies to characterize the CD8⁺ T cell response to SARS-CoV-2 infection at high resolution and compared responses between mild and severe COVID-19.

Results

We observed increased CD8⁺ T cell exhaustion in severe SARS-CoV-2 infection and identified a population of NK-like, terminally differentiated CD8⁺ effector T cells

SUBMITTER: Schreibing F 

PROVIDER: S-EPMC9800604 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature