Zwitterionic rhodamine-CPT prodrug nanoparticles with GSH/H₂O₂ responsiveness for cancer theranostics.

ABSTRACT: Rationale: Fluorescently traceable prodrugs, which can monitor their biodistribution in vivo and track the kinetics of drug delivery in living cells, are promising for constructing theranostic medicines. However, due to their charge and hydrophobicity, most of the fluorescently traceable prodrugs exhibit high protein binding and non-specific tissue retention affecting in vivo distribution and toxicity, with high background signals. Methods: Herein, the zwitterionic rhodamine (RhB) and camptothecin (CPT) were bridged with a disulfide bond to construct a tumorous heterogeneity-activatable prodrug (RhB-SS-CPT). The interaction of zwitterionic RhB-SS-CPT with proteins was detected by UV and fluorescence spectroscopy, and further demonstrated by molecular docking stu

SUBMITTER: Mu X 

PROVIDER: S-EPMC9800722 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature