Empagliflozin inhibits coronary microvascular dysfunction and reduces cardiac pericyte loss in db/db mice.

ABSTRACT:

Background

Coronary microvascular dysfunction (CMD) is a pathophysiological feature of diabetic heart disease. However, whether sodium-glucose cotransporter 2 (SGLT2) inhibitors protect the cardiovascular system by alleviating CMD is not known.

Objective

We observed the protective effects of empagliflozin (EMPA) on diabetic CMD.

Materials and methods

The mice were randomly divided into a db/db group and a db/db + EMPA group, and db/m mice served as controls. At 8 weeks of age, the db/db + EMPA group was given empagliflozin 10 mg/(kg⋅d) by gavage for 8 weeks. Body weight, fasting blood glucose and blood pressure were dynamically observed. Cardiac systolic and diastolic function and coronary flow reserve (CFR) were detected using echocardiography. The coronary microvasc

SUBMITTER: Tu Y 

PROVIDER: S-EPMC9800791 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature