M⁶A regulators featured by tumor immune microenvironment landscapes and correlated with immunotherapy in non-small cell lung cancer (NSCLC).

ABSTRACT:

Introduction

Recent research has confirmed the critical role that epigenetic factors play in regulating the immune response. Nonetheless, what role m⁶A methylation modification might play in the immune response of non-small cell lung cancer (NSCLC) remains vague.

Methods

Herein, the gene expression, copy number variations (CNVs), and somatic mutations of 31 m⁶A regulators in NSCLC and adjacent control samples from the GEO and TCGA databases were comprehensively explored. Using consensus clustering, m⁶A modification patterns were identified. Correlations between m⁶A modification patterns and immune cell infiltration traits in the tumor immune microenvironment (TME) were systematically analyzed. Differentially expressed genes were ve

SUBMITTER: Yuan B 

PROVIDER: S-EPMC9800857 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature