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Spatial repellents: The current roadmap to global recommendation of spatial repellents for public health use.


ABSTRACT: Spatial repellent (SR) products are envisioned to complement existing vector control methods through the continual release of volatile active ingredients (AI) providing: (i) protection against day-time and early-evening biting; (ii) protection in enclosed/semi-enclosed and peri-domestic spaces; (iii) various formulations to fit context-specific applications; and (iv) increased coverage over traditional control methods. SR product AIs also have demonstrated effect against insecticide-resistant vectors linked to malaria and Aedes-borne virus (ABV) transmission. Over the past two decades, key stakeholders, including World Health Organization (WHO) representatives, have met to discuss the role of SRs in reducing arthropod-borne diseases based on existing evidence. A key focus has been to establish a critical development path for SRs, including scientific, regulatory and social parameters that would constitute an outline for a SR target product profile, i.e. optimum product characteristics. The principal gap is the lack of epidemiological data demonstrating SR public health impact across a range of different ecological and epidemiological settings, to inform a WHO policy recommendation. Here we describe in brief trials that are designed to fulfill evidence needs for WHO assessment and initial projections of SR cost-effectiveness against malaria and dengue.

SUBMITTER: Achee NL 

PROVIDER: S-EPMC9801085 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Spatial repellents: The current roadmap to global recommendation of spatial repellents for public health use.

Achee Nicole L NL   Perkins T Alex TA   Moore Sean M SM   Liu Fang F   Sagara Issaka I   Van Hulle Suzanne S   Ochomo Eric O EO   Gimnig John E JE   Tissera Hasitha A HA   Harvey Steven A SA   Monroe April A   Morrison Amy C AC   Scott Thomas W TW   Reiner Robert C RC   Grieco John P JP  

Current research in parasitology & vector-borne diseases 20221209


Spatial repellent (SR) products are envisioned to complement existing vector control methods through the continual release of volatile active ingredients (AI) providing: (i) protection against day-time and early-evening biting; (ii) protection in enclosed/semi-enclosed and peri-domestic spaces; (iii) various formulations to fit context-specific applications; and (iv) increased coverage over traditional control methods. SR product AIs also have demonstrated effect against insecticide-resistant ve  ...[more]

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