Serum Calcitonin Gene-Related Peptide α and β Levels are Increased in COVID-19 Inpatients.

ABSTRACT:

Background

Vasoactive peptides play an important role in a wide range of physiological and pathological conditions. Due to its known functions, the calcitonin gene-related peptide (CGRP) has been suggested as a possible modulator of the hyperimmune response in COVID-19 and thus, blocking its action may lessen the pulmonary effects of COVID-19.

Aim of the study

To compare the circulating levels of CGRPα and CGRPβ in healthy controls compared to hospitalized COVID-19 patients. The study also analyzed how different comorbidities and treatments may affect these concentrations in cases of COVID-19 infection with pulmonary involvement METHODS: Serum samples were collected from the antecubital vein of 51 control subjects (mean age = 55 ± 14 years; range = 26-77; 56.9% female) and 5

SUBMITTER: Garate G 

PROVIDER: S-EPMC9801185 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature