Safety Profile of Linezolid in Older Adults With Renal Impairment: A Population-Based Retrospective Cohort Study.

ABSTRACT:

Background

The objective of this study was to characterize the safety profile of linezolid in patients with renal impairment compared with patients without renal impairment.

Methods

A population-based retrospective cohort study using linked administrative databases included patients aged 66 years or older in Ontario, Canadawho were prescribed linezolid from 2014 to 2021. Renal impairment was defined using baseline estimated glomerular filtration rate <30 mL/min/1.73 m² or receipt of dialysis. The primary outcomes were change in platelet count and severe thrombocytopenia (platelet count <50 × 10⁹/L) within 90 days. Secondary outcomes included bleeding, neutropenia, peripheral neuropathy, optic neuropathy, acidosis, serotonin syndrome, and mortality. Inve

SUBMITTER: Bai AD 

PROVIDER: S-EPMC9801225 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature