Causal associations between gut microbiota and adverse pregnancy outcomes: A two-sample Mendelian randomization study.

ABSTRACT: Growing evidence indicates that gut microbiota could be closely associated with a variety of adverse pregnancy outcomes (APOs), but a causal link between gut microbiome and APOs has yet to be established. Therefore, in this study, we comprehensively investigated the relationship between gut microbiota and APOs to identify specific causal bacteria that may be associated with the development and occurrence of APOs by conducting a two-sample Mendelian randomization (MR) analysis. The microbiome genome-wide association study (GWAS) from the MiBioGen consortium was used as exposure data, and the GWAS for six common APOs was used as outcome data. Single-nucleotide polymorphisms (SNPs) that significantly correlated to exposure, data obtained from published GWAS, were selected as instrumental vari

SUBMITTER: Li C 

PROVIDER: S-EPMC9801412 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature