Dynamic changes of CSF clusterin levels across the Alzheimer's disease continuum.

ABSTRACT:

Background

Clusterin is a multifunctional protein, which is associated with the pathogenesis and the development of Alzheimer's disease (AD). Compared with normal controls, inconsistent results have yielded in previous studies for concentration of cerebrospinal fluid (CSF) clusterin in AD patients. We explored CSF clusterin levels in different pathological processes of AD.

Methods

Following the National Institute on Aging-Alzheimer's Association (NIA-AA) criteria, we employed on the levels of CSF Aβ₄₂(A), phosphorylated-Tau (T), and total-tau (N). Based on previously published cutoffs and the close correlation between CSF p-tau and t-tau, 276 participants from the publicly available ADNI database with CSF biomarkers were divided into four groups: A-(TN)- (normal A

SUBMITTER: Tang L 

PROVIDER: S-EPMC9801612 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature