Improved natural melanin production by Aspergillus nidulans after optimization of factors involved in the pigment biosynthesis pathway.

ABSTRACT:

Background

Melanin is a natural pigment that can be applied in different fields such as medicine, environment, pharmaceutical, and nanotechnology. Studies carried out previously showed that the melanin produced by the mel1 mutant from Aspergillus nidulans exhibits antioxidant, anti-inflammatory, and antimicrobial activities, without any cytotoxic or mutagenic effect. These results taken together suggest the potential application of melanin from A. nidulans in the pharmaceutical industry. In this context, this study aimed to evaluate the effect of factors L-tyrosine, glucose, glutamic acid, L-DOPA, and copper on melanin production by the mel1 mutant and to establish the optimal concentration of these factors to maximize melanin production.

Results

The results showed that L-DO

SUBMITTER: Medeiros WB 

PROVIDER: S-EPMC9801647 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature