New insights into genome annotation in Podospora anserina through re-exploiting multiple RNA-seq data.

ABSTRACT:

Background

Publicly available RNA-seq datasets are often underused although being helpful to improve functional annotation of eukaryotic genomes. This is especially true for filamentous fungi genomes which structure differs from most well annotated yeast genomes. Podospora anserina is a filamentous fungal model, which genome has been sequenced and annotated in 2008. Still, the current annotation lacks information about cis-regulatory elements, including promoters, transcription starting sites and terminators, which are instrumental to integrate epigenomic features into global gene regulation strategies.

Results

Here we took advantage of 37 RNA-seq experiments that were obtained in contrasted developmental and physiological conditions, to complete the functional annotation of

SUBMITTER: Lelandais G 

PROVIDER: S-EPMC9801653 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature