Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.

ABSTRACT:

Study question

What are the cellular composition and single-cell transcriptomic differences between myometrium and leiomyomas as defined by single-cell RNA sequencing?

Summary answer

We discovered cellular heterogeneity in smooth muscle cells (SMCs), fibroblast and endothelial cell populations in both myometrium and leiomyoma tissues.

What is known already

Previous studies have shown the presence of SMCs, fibroblasts, endothelial cells and immune cells in myometrium and leiomyomas. However, there is no information on the cellular heterogeneity in these tissues and the transcriptomic differences at the single-cell level between these tissues.

Study design, size, duration

We collected five leiomyoma and five myometrium samples from a total of eight patients under

SUBMITTER: Goad J 

PROVIDER: S-EPMC9802286 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature