Fast trimer statistics facilitate accurate decoding of large random DNA barcode sets even at large sequencing error rates

ABSTRACT: Abstract Predefined sets of short DNA sequences are commonly used as barcodes to identify individual biomolecules in pooled populations. Such use requires either sufficiently small DNA error rates, or else an error-correction methodology. Most existing DNA error-correcting codes (ECCs) correct only one or two errors per barcode in sets of typically ≲104 barcodes. We here consider the use of random barcodes of sufficient length that they remain accurately decodable even with ≳6 errors and even at

SUBMITTER:  

PROVIDER: S-EPMC9802387 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature