Baroreceptor Sensitivity in Individuals with CKD and Heart Failure

ABSTRACT: Key Points We found that cardiac baroreceptor sensitivity (BRS), which reflects the integrity of autonomic responses to changes in BP, was depressed in individuals with both CKD and heart failure compared with those with heart failure and preserved kidney function. Depressed BRS was associated with the risk of cardiovascular death, whereas CKD in the absence of depressed BRS was not associated with the risk of cardiovascular death. Our findings suggest that depressed BRS may be a critical contributor to the increased risk of cardiovascular death in individuals with CKD and heart failure. Visual Abstract

Background

Heart failure is the most common cardiovascular complication of chronic kidney disease (CKD) and foreshadows a high morbidity and mortality rate. Baroreflex impairment

SUBMITTER: Charytan D 

PROVIDER: S-EPMC9802545 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature