Network-based approach for targeting human kinases commonly associated with amyotrophic lateral sclerosis and cancer.

ABSTRACT:

Background

Amyotrophic Lateral Sclerosis (ALS) is a rare progressive and chronic motor neuron degenerative disease for which at present no cure is available. In recent years, multiple genes encode kinases and other causative agents for ALS have been identified. Kinases are enzymes that show pleiotropic nature and regulate different signal transduction processes and pathways. The dysregulation of kinase activity results in dramatic changes in processes and causes many other human diseases including cancers.

Methods

In this study, we have adopted a network-based system biology approach to investigate the kinase-based molecular interplay between ALS and other human disorders. A list of 62 ALS-associated-kinases was first identified and then we identified the disease associated

SUBMITTER: Khatoon F 

PROVIDER: S-EPMC9802580 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature