Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains.

ABSTRACT: Adaptation to human leukocyte antigen (HLA)-associated immune pressure represents a major driver of human immunodeficiency virus (HIV) evolution at both the individual and population level. To date, there has been limited exploration of the impact of the initial cellular immune response in driving viral adaptation, the dynamics of these changes during infection and their effect on circulating transmitting viruses at the population level. Capturing detailed virological and immunological data from acute and early HIV infection is challenging as this commonly precedes the diagnosis of HIV infection, potentially by many years. In addition, rapid initiation of antiretroviral treatment following a diagnosis is the standard of care, and central to global efforts towards HIV elimination. Yet, acut

SUBMITTER: Alves E 

PROVIDER: S-EPMC9803285 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature