Acquirement of the autonomic nervous system modulation evaluated by heart rate variability in medaka (Oryzias latipes).

ABSTRACT: Small teleosts have recently been established as models of human diseases. However, measuring heart rate by electrocardiography is highly invasive for small fish and not widely used. The physiological nature and function of vertebrate autonomic nervous system (ANS) modulation of the heart has traditionally been investigated in larvae, transparent but with an immature ANS, or in anesthetized adults, whose ANS activity may possibly be disturbed under anesthesia. Here, we defined the frequency characteristics of heart rate variability (HRV) modulated by the ANS from observations of heart movement in high-speed movie images and changes in ANS regulation under environmental stimulation in unanesthetized adult medaka (Oryzias latipes). The HRV was significantly reduced by atropine (1 mM) in the

SUBMITTER: Watanabe-Asaka T 

PROVIDER: S-EPMC9803310 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature