Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs.

ABSTRACT: Homeostatic regulation is essential for stable neuronal function. Several synaptic mechanisms of homeostatic plasticity have been described, but the functional properties of synapses involved in homeostasis are unknown. We used longitudinal two-photon functional imaging of dendritic spine calcium signals in visual and retrosplenial cortices of awake adult mice to quantify the sensory deprivation-induced changes in the responses of functionally identified spines. We found that spines whose activity selectively correlated with intrinsic network activity underwent tumor necrosis factor alpha (TNF-α)-dependent homeostatic increases in their response amplitudes, but spines identified as responsive to sensory stimulation did not. We observed an increase in the global sensory-evoked responses fol

SUBMITTER: Barnes SJ 

PROVIDER: S-EPMC9803349 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature