Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.

ABSTRACT:

Background

The prognostic value of Musashi-2 (MSI2) in human malignancies remains controversial. We thus conducted this meta-analysis to evaluate the association between MSI2 expression and prognosis of patients with malignancies.

Materials and methods

We searched EMBASE, PubMed and Web of Science up to June 2021 for eligible studies. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated to assess the prognostic value of MSI2 expression. Odds ratios (ORs) with 95% CIs were calculated to evaluate the association between MSI2 expression and clinicopathological traits.

Results

Sixteen studies involving 2203 patients were finally included in this meta-analysis. We found that high MSI2 expression might predict unfavorable OS (HR = 1.85, 95% CI: 1.62-2.10,

SUBMITTER: Wu W 

PROVIDER: S-EPMC9803470 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature