Identification of hub genes related to Duchenne muscular dystrophy by weighted gene co-expression network analysis.

ABSTRACT:

Background

The study was aimed to analyze the potential gene modules and hub genes of Duchenne muscular dystrophy (DMD) by weighted gene co-expression network analysis.

Methods

Based on the muscular dystrophy tissue expression profiling microarray GSE13608 from gene expression omnibus, gene co-expression modules were analyzed using weighted gene co-expression network analysis, gene modules related to DMD were screened, gene ontology and Kyoto encyclopedia of genes and genomes enrichment analyses were performed, and signature genes in the modules were screened. The protein-protein interaction network was constructed through Cytoscape, and hub genes were identified. The expression of hub genes in DMD versus normal muscle tissue was calculated in GSE6011.

Results

12 co-e

SUBMITTER: Wei Y 

PROVIDER: S-EPMC9803489 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature