CDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection.

ABSTRACT: Strong epidemiological and pathological evidence supports a role for Chlamydia pneumoniae infection in atherosclerosis and human coronary heart disease. Animal models have shown that C. pneumoniae disseminates hematogenously in infected monocytes and macrophages, while in vitro data suggest that infected macrophages can transmit C. pneumoniae infection directly to endothelial cells. Endothelial cells may be key in vivo targets for C. pneumoniae infection; given that these cells are important in regulating the dynamics of the vessel wall, we used cDNA microarrays to study the transcriptional response of endothelial cells to infection with C. pneumoniae. cDNA arrays were used to characterize the mRNA expression profiles for 268 human genes following infection with C. pneumoniae, which were c

SUBMITTER: Coombes BK 

PROVIDER: S-EPMC98036 | biostudies-literature | 2001 Mar

REPOSITORIES: biostudies-literature