Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype.

ABSTRACT: Schizophrenia is a severe psychiatric disorder determined by a complex mixture of genetic and environmental factors. To better understand the contributions of human genetic variations to schizophrenia, we performed a genome-wide association study (GWAS) of a highly sensitive endophenotype. In this visual masking endophenotype, two vertical bars, slightly shifted in the horizontal direction, are briefly presented (vernier offset). Participants are asked to indicate the offset direction of the bars (either left or right). The bars are followed by a grating mask, which makes the task both spatially and temporally challenging. The inter-stimulus interval (ISI) between the vernier and the mask was determined in 206 patients with schizophrenia, 109 first-order relatives, and 143 controls. Usuall

SUBMITTER: Shaqiri A 

PROVIDER: S-EPMC9803632 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature