Frailty status and risk of irritable bowel syndrome in middle-aged and older adults: A large-scale prospective cohort study.

ABSTRACT:

Background

Frailty is a public health problem for ageing society, however, evidence is lacking regarding its impact on intestinal functions. We aimed to examine prospective relationships of frailty and pre-frailty in middle-aged and older adults with incident irritable bowel syndrome (IBS) in a large-scale population-based cohort.

Methods

Participants (aged 37-73 years) free of IBS, coeliac disease, inflammatory bowel disease and any cancer at baseline were included, using data from the UK Biobank (collected 2006-2010, 22 assessment centres). Participants without available primary care data were excluded. Frailty status was assessed using Fried phenotype including five criteria (weight loss, exhaustion, low grip strength, low physical activity, slow walking pace). Participan

SUBMITTER: Wu S 

PROVIDER: S-EPMC9803645 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature