Cognitive enhancing effects and anticholinesterase activity of stem bark and leaf extracts of Prunus africana.

ABSTRACT: Alzheimer's disease is ranked among the top five causes of death for old people. Globally, it is approximated that there are 7.7 million new cases of Alzheimer's disease per annum and it is expected that by the year 2050, as many as 1.5% of people will be victims of Alzheimers or other types of dementia. Currently there is no cure for Alzheimer's disease and the conventional therapeutics agents available either have low efficacy or are associated with serious side effects. In the current study, in vivo cognitive advancing and anticholinesterase effects of crude methanol extracts of stem bark and leaf of Prunus africana were investigated in scopolamine treated mice. Passive avoidance task was used to evaluate cognitive enhancing effects of the two plant extracts. Donepezil was

SUBMITTER: Ngai DN 

PROVIDER: S-EPMC9803689 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature