Sotorasib in KRAS^G12C mutated lung cancer: Can we rule out cracking KRAS led to worse overall survival?

ABSTRACT: The KRAS oncogene is present in up to 25% of solid tumors and for decades had been undruggable. Sotorasib was the first-in-class KRAS inhibitor to reach the US and European market, and its pharmacological inhibition is restricted to the KRAS p.G12C mutation. Sotorasib showed activity (tumor shrinkage) in patients with non-small cell lung cancer harboring this specific mutation, and efficacy was tested in the CodeBreaK 200, open-label, phase 3 trial (NCT04303780). The results were presented in the ESMO 2022 meeting. CodeBreaK 200 found an improvement in the primary endpoint of progression-free survival (PFS), but overall survival, a key secondary endpoint, was not improved. However, critical questions about the trial's design may limit inferences regarding the reported results. The control

SUBMITTER: Olivier T 

PROVIDER: S-EPMC9803768 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature