Development of novel DNAJB6-KIAA1522-p-mTOR three-protein prognostic prediction models for CRC.

ABSTRACT:

Background

To evaluate the prognostic value of DNAJB6, KIAA1522, and p-mTOR expression for colorectal cancer (CRC) and to develop effective prognostic models for CRC patients.

Methods

The expression of DNAJB6, KIAA1522, and p-mTOR (Ser2448) was detected using immunohistochemistry in 329 CRC specimens. The prognostic values of the three proteins in the training cohort were assessed using Kaplan-Meier curves and univariate and multivariate Cox proportional hazards models. Prediction nomogram models integrating the three proteins and TNM stage were constructed. Subsequently, calibration curves, receiver operating characteristic (ROC) curves, the concordance index (C-index), and decision curve analysis (DCA) were used to evaluate the performance of the nomograms in the training

SUBMITTER: Jiang YJ 

PROVIDER: S-EPMC9803855 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature