Heme-heme oxygenase-2 reduces the atherosclerosis by preventing inflammation.

ABSTRACT:

Objective

Heme oxygenase (HO) has been shown to have important antioxidant and anti-inflammatory properties, resulting in a vascular antitherogenic effect. This study was undertaken to evaluate the role of HO-2 in atherosclerosis.

Method and results

The expression levels of HO-2 were evaluated in M1 and M2 bone marrow macrophage induced by LPS and IL4. The expression of HO-2 was significantly higher in M2 macrophage than in M1 macrophage. Western diet (WD) caused a significant increase in HO-2 expression in ApoE^-/- mice. The adeno-associated viral (AAV) vectors expressing HO-2 was constructed, and the mice were received saline (ApoE^-/-), AAV (ApoE^-/-), AAV-HO-2 (ApoE^-/-) on WD at 12 weeks and their plasma lipids, inflammatory cytoki

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9804009 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature