Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.

ABSTRACT:

Aims

Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment. We aimed to explore the mechanism underlying this resistance.

Methods

Pentylenetetrazol-induced chronic epileptic rats were administered VPA (250 mg/Kg) for 14 days; rats with controlled seizure stages (seizure score^14th-before  ≤0) and latent time (latent time^14th-before  ≥0) were considered VPA-responsive, while the others were considered nonresponsive. Differentially expressed genes (DEGs) between the VPA-responsive and nonresponsive rat hippocampus transcriptomes were identified, and their functions were evaluated. The roles of postsynaptic density (PSD) and Homer1 were also determined. Furthermore, a subtype of Homer1 (Homer1b/c) was overexpressed or silenced in HT2

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9804053 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature