The Prognostic and Predictive Effects of Human Papillomavirus Status in Hypopharyngeal Carcinoma: Population-Based Study.

ABSTRACT:

Background

The role of the Human Papillomavirus (HPV) status in patients with hypopharyngeal squamous cell carcinoma (HSCC) remains controversial.

Objective

Our aim was to determine the prognostic and predictive effects of HPV status in patients with locally advanced HSCC (stage III-IVB) receiving primary radiotherapy.

Methods

Patients diagnosed with stage III-IVB HSCC between 2010 and 2016 were identified. HPV status, demographics, clinicopathological characteristics, treatment, and survival data were captured. Kaplan-Meier analysis, multivariable Cox regression analysis, and propensity score matching analysis were performed.

Results

We identified 531 patients in this study and 142 (26.7%) patients with HPV-positive diseases. No significant differences were ob

SUBMITTER: Yang SP 

PROVIDER: S-EPMC9804097 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature