Processability of mesoporous materials in fused deposition modeling for drug delivery of a model thermolabile drug

ABSTRACT: The incorporation of drug-loaded mesoporous materials in dosage forms prepared with fused deposition modeling (FDM) has shown the potential to solve challenges relating to additive manufacturing techniques, such as the stability of poorly-soluble drugs in the amorphous state. However, the addition of these non-melting mesoporous materials significantly affects the mechanical properties of the filament used in FDM, which in turn affects the printability of the feedstock material. Therefore, in this study a full-factorial experimental design was utilized to investigate different processing parameters of the hot melt extrusion process, their effect on various mechanical properties and the potential correlation with the filaments' printability. The thermolabile, poorly-soluble drug ibuprofen w

SUBMITTER:  

PROVIDER: S-EPMC9804103 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature