Inkjet drug printing onto contact lenses: Deposition optimisation and non-invasive dose verification.

ABSTRACT: Inkjet printing has the potential to advance the treatment of eye diseases by printing drugs on demand onto contact lenses for localised delivery and personalised dosing, while near-infrared (NIR) spectroscopy can further be used as a quality control method for quantifying the drug but has yet to be demonstrated with contact lenses. In this study, a glaucoma therapy drug, timolol maleate, was successfully printed onto contact lenses using a modified commercial inkjet printer. The drug-loaded ink prepared for the printer was designed to match the properties of commercial ink, whilst having maximal drug loading and avoiding ocular inflammation. This setup demonstrated personalised drug dosing by printing multiple passes. Light transmittance was found to be unaffected by drug loading on the c

SUBMITTER: Pollard TD 

PROVIDER: S-EPMC9804110 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature