Pyrimidopteridine-catalyzed Photo-mediated Hydroacetoxylation.

ABSTRACT: Herein we report a photo-mediated formal addition of carboxylic acids to activated alkenes catalyzed by a pyrimidopteridine photoredox catalyst. The decarboxylation of aliphatic carboxylic acids upon single-electron oxidation is countered in the presence of electron-rich alkenes and a hydroacetoxylation is observed. Mechanistic proposals have been made based on CV measurements, competitive Stern-Volmer quenching and EPR experiments. Evidence that tetra-N-substituted pyrimidopteridines function as dual photoredox and hydrogen atom transfer catalyst was supported by spectroscopic means.

SUBMITTER: Petrosyan A 

PROVIDER: S-EPMC9804165 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature