Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease.

ABSTRACT:

Background

Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for risk stratification is uncertain.

Methods

We assessed prospective relationships of plasma TMAO with long-term risk of all-cause, cardiovascular (CV), and non-CV mortality in the Western Norway Coronary Angiography Cohort (WECAC; 4132 patients with suspected coronary artery disease) and the Hordaland Health Study (HUSK; 6393 community-based subjects). Risk associations were examined using Cox regression analyses.

Results

Mean follow-up was 9.8 and 10.5 years in WECAC and HUSK, respectively. Following adjustments for established CV risk factors and indice

SUBMITTER: Bjornestad EO 

PROVIDER: S-EPMC9804190 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature