Mobilisation of HLA-F on the surface of bronchial epithelial cells and platelets in asthmatic patients.

ABSTRACT: Uncontrolled inflammation of the airways in chronic obstructive lung diseases leads to exacerbation, accelerated lung dysfunction and respiratory insufficiency. Among these diseases, asthma affects 358 million people worldwide. Human bronchial epithelium cells (HBEC) express both anti-inflammatory and activating molecules, and their deregulated expression contribute to immune cell recruitment and activation, especially platelets (PLT) particularly involved in lung tissue inflammation in asthma context. Previous results supported that HLA-G dysregulation in lung tissue is associated with immune cell activation. We investigated here HLA-F expression, reported to be mobilised on immune cell surface upon activation and displaying its highest affinity for the KIR3DS1-activating NK receptor. We

SUBMITTER: Fiouane S 

PROVIDER: S-EPMC9804204 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature