Synthesis of ¹³ C and ² H Labeled Vinyl Pyruvate and Hyperpolarization of Pyruvate.

ABSTRACT: The hyperpolarization of nuclear spins has enabled unique applications in chemistry, biophysics, and particularly metabolic imaging. Parahydrogen-induced polarization (PHIP) offers a fast and cost-efficient way of hyperpolarization. Nevertheless, PHIP lags behind dynamic nuclear polarization (DNP), which is already being evaluated in clinical studies. This shortcoming is mainly due to problems in the synthesis of the corresponding PHIP precursor molecules. The most widely used DNP tracer in clinical studies, particularly for the detection of prostate cancer, is 1-¹³ C-pyruvate. The ideal derivative for PHIP is the deuterated vinyl ester because the spin physics allows for 100 % polarization. Unfortunately, there is no efficient synthesis for vinyl esters of β-ketocarboxylic acid

SUBMITTER: Brahms A 

PROVIDER: S-EPMC9804285 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature